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Click on any project title for a more detailed description of the project. For more information about any of these awards (e.g., PI contact information or associated publications), please use the corresponding project number to search for information at the NIH Reporter website. Consistent with NIH policy, abstracts are not available for projects receiving their first award within the past year, so descriptions provided below are from the NCI program director.

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Award
Type
Project # Year
of Award
PI Name(s)
All
Institution Title
Abstract Text (Official)
R21 CA186853-01 2014 CHEN, XIAOWEI RESEARCH INST OF FOX CHASE CAN CTR A Novel Allele-Specific RNA-ISH for Differential Allele-specific Expression
A new method for differential allele-specific expression (DASE) for single cell level studies and compatible with FFPE treatment so that DASE can be assessed cell by cell across FFPE samples.
 
R21 CA186798-01 2014 CHIU, DANIEL T UNIVERSITY OF WASHINGTON Ultra-Bright Probes with Ultra-Narrow Emission for Molecular and Cellular Analysis
Modification of polymer dot fluorescent markers to improve key fabrication steps to make improve their performance over quantum dots.
 
R21 CA177391-01A1 2014 CIMA, MICHAEL J MASSACHUSETTS INSTITUTE OF TECHNOLOGY Implantable device for high-throughput in vivo drug sensitivity testing
Small implantable capsules with etched reservoirs that contain micro-doses of therapeutic agents in which the immediate periphery around each reservoir is can independently monitored to assess independent and combination drug response for therapeutic efficacy.
 
R21 CA182336-01A1 2014 ISSADORE, DAVID AARON UNIVERSITY OF PENNSYLVANIA A micro Hall chip for circulating microvesicle based cancer monitoring
A device targeting the isolation and capture of circulating microvessicles from whole blood using a magnetic nanoparticles in a micro flow cytometer like approach.
 
R21 CA174573-01A1 2014 KUMAR, SANJAY UNIVERSITY OF CALIFORNIA BERKELEY Molecular analysis of physical microenvironmental control of tumor cell invasion
Novel platform for studying regulation of cancer cell migration in 3D and monitoring underlying molecular pathways, with exquisite control over ECM stiffness, geometry, and biochemistry, along with ability to screen the impact of various inhibitors on motility.
 
R21 CA183660-01 2014 LEVENSON, RICHARD M.; BOROWSKY, ALEXANDER D UNIVERSITY OF CALIFORNIA DAVIS Highly multiplexed ion-beam tissue RNA in situ imaging with sub-micron resolution
Application of mass-based metallic tags to detecting RNA in FFPE tissue using a tightly focused beam and paired detector, rather than broad incident laser light and tracking fluorescence, with ability to track up to 100 different targets simultaneously.
 
R21 CA177457-01A1 2014 PETRITIS, KONSTANTINOS; CARPENTIERI, DAVID TRANSLATIONAL GENOMICS RESEARCH INST Preservation of Dried Plasma Spots for downstream proteomic applications
Develop an effective method for spotting plasma on filter paper in such a way that optimally preserves proteins for downstream analysis by mass spectrometry.
 
R21 CA183627-01 2014 PETUKHOV, PAVEL A (contact); FRASOR, JONNA UNIVERSITY OF ILLINOIS AT CHICAGO Photoreactive histone deacetylase probes for chromatin immunoprecipitation in cancer
To replace antibodies used in chromatin immunoprecipitation (ChIP) assays with photoreactive probes with high sensitivity/specificity for histone deacetylase isoforms.
 
R21 CA177395-01A1 2014 RIETHMAN, HAROLD C. (contact); XIAO, MING WISTAR INSTITUTE A novel single-molecule telomere characterization technology for analyzing cancer
To develop  novel methods called nick-nucleotide (NN) and  nick-gap-oligonucleotide (NGO), for labeling subtelomeric sequences adjacent to telomeres on each chromosome, then convert to dsDNA for massively parallel single-molecule sequence analysis using nanochannel array technology. This technique would allow for high-throughput allele-specific screening of telomere length at single molecule resolution on a genome-wide scale.
 
R21 CA186791-01 2014 SEIBEL, ERIC J UNIVERSITY OF WASHINGTON Needle biopsy preservation and preparation for rapid 3D pathology of pancreas
a new microfluidic platform to automate the processing of needle biopsy cores, including standard fixation by formalin, staining with a variety of stains, and imaging the processed cores in 3D, in which the goal is to maintain the cellular structure and context of cancer cells throughout processing in such a way that could substantially affect conventional pathology for diagnosing these kinds of samples.
 
R21 CA174537-01A1 2014 TEMPST, PAUL SLOAN-KETTERING INST CAN RESEARCH Immobilized protease activity tests for developing functional cancer biomarkers.
To develop novel, highly specific enzymatic activity assays, based on antibody-mediated capture, to screen for differential patterns of blood protease activities with the aim to identify biomarkers for cancer proliferation, recurrence and response to therapy.
 
R21 CA181855-01A1 2014 VARANI, JAMES UNIVERSITY OF MICHIGAN AT ANN ARBOR Isolation and in vitro maintenance of intact colonic crypts from normal human colon
To develop a relatively low-cost and simple method for isolating and culturing 1000s of highly representative replicate crypts from small amounts of starting material from both normal and cancerous colon tissue to overcome shortcomings associated with the variety of current techniques for studying early-stage transformation of these structures.
 
R21 CA186809-01 2014 WANG, TZA-HUEI JOHNS HOPKINS UNIVERSITY Digital Detection of Tumor-Derived Circulating Methylated DNA
Develop a microfluidic platform to detect cell-free methylated DNA in plasma with substantially greater sensitivity and broader detection capability than current digital PCR approaches like Methyl-BEAMing and much cheaper than NGS-based approaches.
 
R21 CA177467-01A1 2014 WHITE, KEVIN P. (contact); LANGERMAN, ALEXANDER JAY UNIVERSITY OF CHICAGO Micro-western array methodology for assessment of preanalytical variability in biospecimens
To combine quantitative micro-western arrays and reverse-phase protein arrays to characterize the impact of preanalytical sources of sample degradation
 
R21 CA177479-01A1 2014 ZAIA, JOSEPH BOSTON UNIVERSITY MEDICAL CAMPUS Quantitative profiling of glycosaminoglycans from breast tumor tissue arrays
Develop a new protocol for processing of graded and staged tissue microarrays for analysis of their glycosaminoglycan populations via mass spectrometry. The approach involves precise microinjection printing of glycosidases and subsequent extraction of digested material for LC-MS quantification of specific glycosaminoglycans.
 
R21 CA186846-01 2014 ZENG, YONG UNIVERSITY OF KANSAS LAWRENCE Integrated Microfluidic Exosome Profiling for Early Detection of Cancer
Develop a platform for capture from plasma of circulating exosomes and analysis of extracted proteins all on the same microfluidic chip.
 
R21 CA174543-01A1 2014 ZILBERBERG, JENNY (contact); LEE, WOO YOUNG HACKENSACK UNIVERSITY MEDICAL CENTER "Microfluidic approach for the development of a three-dimensional bone marrow microenvironment model to test personalized multiple myeloma treatments"
To create a microfluidics-driven 3D tissue culturing platform that replicates the microenvironment required for multiple myeloma survival, implementing a number of analytical components to verify recapitulation of in vivo conditions and the ability to study multiple parameters simultaneously.
 
R33 CA177449-01A1 2014 BLAIR, SARAH L UNIVERSITY OF CALIFORNIA SAN DIEGO Non-Circulating Microparticles for Improved Localization and Resection Cancer
Further develop a platform using microbubbles during preoperative radiology as marking agents of breast tumor boundaries to ensure positive margins on subsequent resection.
 
R33 CA177333-01A1 2014 FEDERSPIEL, MARK J MAYO CLINIC ROCHESTER Validating Technology To Optimize Antibody Affinity For Targeting Therapeutics
Further develop a new eukaryotic polypeptide display platform based on Avian Leukosis Virus to ultimately identify better affinity reagents for cancer targets.
 
R33 CA183685-01 2014 HANSEN, KIRK C (contact); WEAVER, VALERIE MARIE UNIVERSITY OF COLORADO DENVER Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor Microenvironment
To build upon a successful IMAT R21-supported project to improve proteomic analysis of the ECM (by using) a variety of approaches, including pulsed 13C-labeling of proteins, MRM-MS and (isostable) affinity tagging (for ability) will be used to investigate the composition of the ECM in relation to tumor development and metastasis. They will validate the approach on established murine models for breast and pancreatic cancer.
 
R33 CA181771-01A1 2014 LOEB, LAWRENCE A UNIVERSITY OF WASHINGTON Validation and Advanced Development of Duplex Sequencing
Optimize and validate "Duplex Sequencing" technique, involving the use of unique identifier tag sequences to permit grouping of PCR products that can subsequently allow for tracking of complementary alleles and scoring of mutations only if they are detected in both alleles.
 
R33 CA183654-01 2014 NOLAN, GARRY P STANFORD UNIVERSITY Highly multiplexed ion-beam tissue molecular imaging with sub-micron resolution
To further develop Molecular Ion Beam Imaging technology, by expanding multiplexing capacity to as many as 100 protein targets simultaneously, with approximately 50nm lateral spatial resolution, and validating its use with formalin-fixed, paraffin-embedded samples.
 
R33 CA183671-01 2014 PARKER, LAURIE L. UNIVERSITY OF MINNESOTA Multiplexed Kinase Biosensor Technology to Detect Leukemia Signaling with Mass Spectrometry
Further develop kinase nanoprobes capable of detecting the activity and inhibition of specific kinases or kinase families in intact, live cells.
 
R33 CA183659-01 2014 ROBINSON, WILLIAM H STANFORD UNIVERSITY Large-Scale Characterization of Anti-Cancer Antibody Responses in Lung Adenocarcinoma
To pursue further development of the "antibody repertoire capture" (ARC) technique for identification and characterization of novel anti-tumor autoantibodies, with the potential to serve both diagnostic and therapeutic applications. The focus will be on improved throughput and better specificity of candidates.
 
R33 CA186795-01 2014 TURESKY, ROBERT J. UNIVERSITY OF MINNESOTA Carcinogen DNA adduct biomarkers in formalin fixed tissues
Further develop and validate a method for using reagents from a commercially available PCR prep kit to recover DNA from FFPE tissue in a way that uniquely preserves adducts on the bases.
 
R33 CA183692-01 2014 WEISS, WILLIAM A UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Integrating mass cytometric and transcriptomic profiles of solid tumors
To pursue further development of a non-optical based flow cytometry platform (mass cytometry) with the ability to characterize target cells based on up to 45 different markers simultaneously, for extracting and analyzing single cells with a broader view to more robustly characterizing tumor heterogeneity, and focusing on GBM for validation of the tool. Results to be compared directly with microarray data from clinical samples to corroborate characterization.