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Click on any project title for a more detailed description of the project. For more information about any of these awards (e.g., PI contact information or associated publications), please use the corresponding project number to search for information at the NIH Reporter website. Consistent with NIH policy, abstracts are not available for projects receiving their first award within the past year, so descriptions provided below are from the NCI program director.

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Award
Type
Project # Year
of Award
PI Name(s)
All
Institution Title
Abstract Text (Official)
R21 CA174573-01A1 2014 KUMAR, SANJAY UNIVERSITY OF CALIFORNIA BERKELEY Molecular analysis of physical microenvironmental control of tumor cell invasion
Novel platform for studying regulation of cancer cell migration in 3D and monitoring underlying molecular pathways, with exquisite control over ECM stiffness, geometry, and biochemistry, along with ability to screen the impact of various inhibitors on motility.
 
R21 CA183627-01 2014 PETUKHOV, PAVEL A (contact); FRASOR, JONNA UNIVERSITY OF ILLINOIS AT CHICAGO Photoreactive histone deacetylase probes for chromatin immunoprecipitation in cancer
To replace antibodies used in chromatin immunoprecipitation (ChIP) assays with photoreactive probes with high sensitivity/specificity for histone deacetylase isoforms.
 
R21 CA177395-01A1 2014 RIETHMAN, HAROLD C. (contact); XIAO, MING WISTAR INSTITUTE A novel single-molecule telomere characterization technology for analyzing cancer
To develop  novel methods called nick-nucleotide (NN) and  nick-gap-oligonucleotide (NGO), for labeling subtelomeric sequences adjacent to telomeres on each chromosome, then convert to dsDNA for massively parallel single-molecule sequence analysis using nanochannel array technology. This technique would allow for high-throughput allele-specific screening of telomere length at single molecule resolution on a genome-wide scale.
 
R21 CA174537-01A1 2014 TEMPST, PAUL SLOAN-KETTERING INST CAN RESEARCH Immobilized protease activity tests for developing functional cancer biomarkers.
To develop novel, highly specific enzymatic activity assays, based on antibody-mediated capture, to screen for differential patterns of blood protease activities with the aim to identify biomarkers for cancer proliferation, recurrence and response to therapy.
 
R21 CA177467-01A1 2014 WHITE, KEVIN P. (contact); LANGERMAN, ALEXANDER JAY UNIVERSITY OF CHICAGO Micro-western array methodology for assessment of preanalytical variability in biospecimens
To combine quantitative micro-western arrays and reverse-phase protein arrays to characterize the impact of preanalytical sources of sample degradation
 
R21 CA174543-01A1 2014 ZILBERBERG, JENNY (contact); LEE, WOO YOUNG HACKENSACK UNIVERSITY MEDICAL CENTER "Microfluidic approach for the development of a three-dimensional bone marrow microenvironment model to test personalized multiple myeloma treatments"
To create a microfluidics-driven 3D tissue culturing platform that replicates the microenvironment required for multiple myeloma survival, implementing a number of analytical components to verify recapitulation of in vivo conditions and the ability to study multiple parameters simultaneously.
 
R33 CA183685-01 2014 HANSEN, KIRK C (contact); WEAVER, VALERIE MARIE UNIVERSITY OF COLORADO DENVER Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor Microenvironment
To build upon a successful IMAT R21-supported project to improve proteomic analysis of the ECM (by using) a variety of approaches, including pulsed 13C-labeling of proteins, MRM-MS and (isostable) affinity tagging (for ability) will be used to investigate the composition of the ECM in relation to tumor development and metastasis. They will validate the approach on established murine models for breast and pancreatic cancer.
 
R33 CA183654-01 2014 NOLAN, GARRY P STANFORD UNIVERSITY Highly multiplexed ion-beam tissue molecular imaging with sub-micron resolution
To further develop Molecular Ion Beam Imaging technology, by expanding multiplexing capacity to as many as 100 protein targets simultaneously, with approximately 50nm lateral spatial resolution, and validating its use with formalin-fixed, paraffin-embedded samples.
 
R33 CA183659-01 2014 ROBINSON, WILLIAM H STANFORD UNIVERSITY Large-Scale Characterization of Anti-Cancer Antibody Responses in Lung Adenocarcinoma
To pursue further development of the "antibody repertoire capture" (ARC) technique for identification and characterization of novel anti-tumor autoantibodies, with the potential to serve both diagnostic and therapeutic applications. The focus will be on improved throughput and better specificity of candidates.
 
R33 CA183692-01 2014 WEISS, WILLIAM A UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Integrating mass cytometric and transcriptomic profiles of solid tumors
To pursue further development of a non-optical based flow cytometry platform (mass cytometry) with the ability to characterize target cells based on up to 45 different markers simultaneously, for extracting and analyzing single cells with a broader view to more robustly characterizing tumor heterogeneity, and focusing on GBM for validation of the tool. Results to be compared directly with microarray data from clinical samples to corroborate characterization.