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Eighth Principal Investigators Meeting Agenda

Eighth Principal Investigators Meeting
Innovative Molecular Analysis Technologies (IMAT) Program
July 24-25, 2007
Sofitel San Francisco Bay
Redwood City, CA

Agenda

Scientific Theme:

Integrating Technology Platforms:
Separation, Detection, Analysis, and Data Management

Tuesday, July 24, 2007

7:00 a.m. - 7:00 p.m.

Registration
Ballroom Foyer

7:00 a.m. - 8:00 a.m.

Breakfast
Ballroom Foyer

7:00 a.m. - 8:00 p.m.

Poster Setup
Champagne

8:00 a.m. - 8:15 a.m.

Welcoming Remarks and Introduction of IMAT Program
Bordeaux

Carolyn C. Compton, M.D., Ph.D.
Office of Biorepositories and Biospecimen Research
National Cancer Institute, NIH

J. Randy Knowlton, Ph.D.
Division of Cancer Biology
National Cancer Institute, NIH

8:15 a.m. - 9:00 a.m.

Keynote Speaker

Translation of Technical Development into the Clinical Laboratory
Frederic M. Waldman, M.D., Ph.D.
University of California, San Francisco

9:00 a.m. - 10:20 a.m.

Scientific Session I: Gold Standards, Cool Samples, and Analysis—Part 1
Moderator: J. Randy Knowlton, Ph.D.
National Cancer Institute, NIH

9:00 a.m. - 9:20 a.m.

Evaluation of the Value of Frozen Tissue Section Used as the Gold Standard for Immunohistochemistry
Shan-Rong Shi, M.D.
University of Southern California

9:20 a.m. - 9:50 a.m.

Tissue Print Micropeels for the Molecular Profiling of Cancer
Sandra M. Gaston, Ph.D.
Beth Israel Deaconess Medical Center/Harvard Medical School

9:50 a.m. - 10:20 a.m.

Molecular Analysis of EGF Receptor (EGFR) Expression and Activation Using Nanostructured Surfaces and Liquid Crystal-Based Technologies
Paul J. Bertics, Ph.D.
University of Wisconsin-Madison

10:20 a.m. - 10:40 a.m.

BREAK
Ballroom Foyer

10:40 a.m. - 11:40 a.m.

Scientific Session I: Gold Standards, Cool Samples, and Analysis—Part 2
Bordeaux

Moderator: J. Randy Knowlton, Ph.D.
National Cancer Institute, NIH

10:40 a.m. - 11:10 a.m.

Application of a Sensitive Double-Clad Optical Fiber for Two-Photon Fluorescence Measurement in Tissues
James R. Baker, Jr., M.D.
University of Michigan

11:10 a.m. - 11:40 a.m.

Identification of Immune-Selected Breast Cancer Antigens
Kevin Claffey, Ph.D.
University of Connecticut Health Center

11:40 a.m. - 11:55 a.m.

IMAT Review
Jeffrey E. DeClue, Ph.D.
Division of Extramural Activities
National Cancer Institute, NIH

11:55 a.m. - 12:15 p.m.

NCI/NIH Research Resources for the IMAT Investigator
James W. Jacobson, Ph.D.
National Cancer Institute, NIH

12:15 p.m. - 1:30 p.m.

Lunch and Posters
Ballroom Foyer/Champagne

1:30 p.m. - 2:45 p.m.

The Cancer Genome Atlas (TCGA)
Bordeaux

Moderator: Carolyn C. Compton, M.D., Ph.D.
National Cancer Institute, NIH

1:30 p.m. - 1:55 p.m.

What Is TCGA, and What Are TCGA's Technology Needs?
Daniela S. Gerhard, Ph.D.
Director, Office of Cancer Genomics
National Cancer Institute, NIH

1:55 p.m. - 2:45 p.m.

TCGA-Related Technical Developments

1:55 p.m. - 2:20 p.m.

Exon-Specific Sequencing of Whole Genomic DNA
Darren R. Link, Ph.D.
RainDance Technologies, Inc.

2:20 p.m. - 2:45 p.m.

Mapping the Transcriptional Regulatory Networks and Epigenome of Cancer Cells: A ChIP-chip Approach
Bing Ren, Ph.D.
Ludwig Institute for Cancer Research/University of California, San Diego

2:45 p.m. - 3:30 p.m.

Keynote Presentation

Pathways-Based Analysis of Cancer Progression From High-Throughput Data
Sylvia K. Plevritis, Ph.D.
Stanford University

3:30 p.m. - 3:50 p.m.

BREAK
Ballroom Foyer

3:50 p.m. - 5:50 p.m.

Scientific Session II: FFPE Samples: Turning Lead Into Gold
Bordeaux

Moderator: Lynn R. Sorbara, Ph.D.
National Cancer Institute, NIH

3:50 p.m. - 4:20 p.m.

Starting Material Degradation Test Is Tied to Success in Whole-Genome Amplification From Diverse Clinical Samples
G. Mike Makrigiorgos, Ph.D.
Dana Farber Cancer Institute/Harvard Medical School

4:20 p.m. - 4:50 p.m.

Ultrasound Tissue Fixation and Processing Achieve Superior Morphology and Macromolecule Integrity
Wei-Sing Chu, M.D.
U.S. Department of Veterans Affairs

4:50 p.m. - 5:20 p.m.

Automated, Whole-Slide-Based, Multiplexed Molecular Marker Assessment in Formalin-Fixed, Paraffin-Embedded Tissues
Richard M. Levenson, M.D.
Cambridge Research & Instrumentation, Inc.

5:20 p.m. - 5:50 p.m.

Expression Profiling in Paraffin-Embedded Tissues and Patient Cell Lines Reveals Predictive Markers in Intestinal Tumorigenesis and Colorectal Cancer Treatment
Rossanna C. Pezo, M.S.
Albert Einstein College of Medicine

6:00 p.m. - 8:00 p.m.

Poster Session and Reception
Champagne

6:00 p.m. - 7:00 p.m.

Odd poster numbers will stand by their posters for Q&A.

7:00 p.m. - 8:00 p.m.

Even poster numbers will stand by their posters for Q&A.

Wednesday, July 25, 2007

7:00 a.m. - 8:00 a.m.

Breakfast and Posters
Ballroom Foyer/Champagne

7:30 a.m. - 3:30 p.m.

Registration
Ballroom Foyer

8:00 a.m. - 10:20 a.m.

$$$Future Potential$$$
Bordeaux

Moderator: Jennifer Couch, Ph.D.
Division of Cancer Biology
National Cancer Institute, NIH

8:00 a.m. - 8:40 a.m.

Topic 1: Downstream Funding Opportunities

8:00 a.m. - 8:15 a.m.

Jennifer Couch, Ph.D.
Division of Cancer Biology
National Cancer Institute, NIH

8:15 a.m. - 8:40 a.m.

Rohit K. Shukla, M.A.
Commercialization Assistance Program Representative
Larta Institute

8:40 a.m. - 10:20 a.m.

Topic 2: Technology Transfer

8:40 a.m. - 8:55 a.m.

Kevin Brand, J.D.
Technology Transfer Center
National Cancer Institute, NIH

8:55 a.m. - 9:10 a.m.

J.P. Kim, J.D., M.B.A., M.S.
Division of Extramural Inventions and Technology
National Cancer Institute, NIH

9:10 a.m. - 9:25 a.m.

Wendy D. Streitz, M.S.E.E.
Policy, Analysis, and Campus Services
University of California System

9:25 a.m. - 9:40 a.m.

Novel 3-D Tissue Imaging: A Multi-Dimensional Story of Technology Development
Bevin P. Engelward, Sc.D.
Massachusetts Institute of Technology

9:40 a.m. - 10:20 a.m.

Panel Discussion for Technology Transfer Extramural Community (Licensing Technologies, Intellectual Properties, and Patent MTAs and CDAs)

10:20 a.m. - 10:40 a.m.

BREAK
Ballroom Foyer

10:40 a.m. - 11:25 a.m.

Keynote Presentation
Bordeaux

Genomic Data Management and Analysis: Good, Bad, and Ugly
Timothy J. Triche, M.D., Ph.D.
Children's Hospital Los Angeles

11:25 a.m. - 12:30 p.m.

Lunch and Posters
Ballroom Foyer/Champagne

12:30 p.m. - 3:30 p.m.

Scientific Session III: Circulating Cells: Catch Me If You Can
Moderator: James W. Jacobson, Ph.D.
National Cancer Institute, NIH

12:30 p.m. - 1:00 p.m.

Integrated Polymer-Based Microfluidic Systems for the Efficient Capture and Enumeration of Circulating Tumor Cells (CTCs) From Peripheral Blood
Steven A. Soper, Ph.D.
Louisiana State University

1:00 p.m. - 1:30 p.m.

Chip-Based RNA Sensor Platform for the Detection of Circulating Tumor Cells
Gary A. Clawson, M.D., Ph.D.
The Pennsylvania State University

1:30 p.m. - 2:00 p.m.

Activity-Based Probes for Profiling Histone Deacetylase Complexes in Proteomes
Cleo M. Salisbury, Ph.D.
The Scripps Research Institute

2:00 p.m. - 2:30 p.m.

Developing Proteomic Technologies for Rapid, Real-Time, Label-Free Detection of Protein Interactions
Niroshan Ramachandran, Ph.D.
Harvard Medical School/Dana-Farber Cancer Institute

2:30 p.m. - 3:00 p.m.

Clinical Application of Multispectral Imaging Flow Cytometry
Hans Minderman, Ph.D.
Roswell Park Cancer Institute

3:00 p.m. - 3:30 p.m.

Phosphoprotein Profiling for Quantitative Analysis of Protein Phosphorylation Patterns
Stephen Kron, M.D., Ph.D.
The University of Chicago

3:30 p.m.

Adjournment and Poster Removal