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Ninth Principal Investigators Meeting Agenda


Ninth Principal Investigators Meeting
Innovative Molecular Analysis Technologies (IMAT) Program
October 26-28, 2008
Hyatt Regency Cambridge
President's Ballroom

Sunday, October 26, 2008

2:00 p.m. - 8:30 p.m.

Registration and Poster Setup

3:00 p.m. - 3:15 p.m.

Welcome and Introductions

3:15 p.m. - 5:00 p.m.

Scientific Session 1: Technologies To Capture Circulating Tumor Cells (CTCs)
Moderator: Paul Wanger, Ph.D.
National Cancer Institute, NIH

Development of a Membrane Microfilter Device for Capture and Characterization of CTCs in Blood
Richard J. Cote, M.D.
University of Southern California

Development of an RNA Sensor Platform for Detection of CTCs
Gary Clawson, M.D., Ph.D.
The Pennsylvania State University

Isolation of Rare Cells From Whole Blood Using Microfluidics
Lance L. Munn, Ph.D.
Harvard Medical School

Performance Characteristics of a New CTC Enrichment Method Using a Negative Selection Strategy
Steven Bogen, M.D., Ph.D.
Boston University

5:00 p.m. - 5:15 p.m.


5:15 p.m. - 6:15 p.m.

Keynote Address: When Quality Matters Most: Driving Innovative Research and Develoment Through Emerging Paradigms in Biospecimen Science and Utilization
Carolyn C. Compton, M.D., Ph.D.
National Cancer Institute, NIH

6:15 p.m. - 7:15 p.m.

Prospects and Possibilities
Moderator: J. Randy Knowlton, Ph.D.
National Cancer Institute, NIH

Funding Opportunities and Strategies for Moving Your Research Forward
Jennifer Couch, Ph.D.
National Cancer Institute, NIH

Center to Reduce Cancer Health Disparaties and IMAT: Fostering Collaborations, Exploring Synergies and Reducing Cancer Health Disparities
LeeAnn Bailey, Ph.D.
National Cancer Institute, NIH

The Biospecimen Research Network: A Resource For Technology Development
Mark D. Lim, Ph.D.
National Cancer Institute, NIH

Monday, October 27, 2008

7:00 a.m. - 8:00 a.m.

Registration and Continental Breakfast

8:00 a.m. - 8:45 a.m.

Keynote Address: Mass Spectrometry-Based Proteomic Approaches for the Discovery of Disease Biomarkers for Lymphoma
Megan S. Lim, M.D., Ph.D.
University of Michigan

8:45 a.m. - 10:30 a.m.

Scientific Session II: New Technologies for Sample Preparation
Moderator: Lynn R. Sorbara, Ph.D.
National Cancer Institute, NIH

High Resolution Karyotype Analysis of Single Cells Using BAC-FISH Assays
Heinz-Ulrich Weier, Ph.D.
Lawrence Berkeley National Laboratory

Magnetically Patterned Co-Cultures for Cancer Studies
Daniel H. Reich, Ph.D.
John Hopkins University

Microfluidic Channels for High-Density, High-Performance Culture Assays
David J. Beebe, Ph.D.
University of Wisconsin

Sample Preparation Methods for Microvessel Analysis in Tumors
Rosalinda Sepulveda, M.D.
Harvard School of Public Health

10:30 a.m. - 10:45 a.m.


10:45 a.m. - 12:30 p.m.

Scientific Session III: New Technologies for Genomic Analysis
Moderator: Jay N. Choudry
National Cancer Institute, NIH

Interaction-Specific Network Perturbation of Disease Proteins
Marc Vidal, Ph.D.
Dana-Farber Cancer Institute

Impact of q-RT-PCR Analytical Methods on a Multicenter Biomarker Trial in Colorectal Cancer
Terry Hyslop, Ph.D.
Thomas Jefferson University

Sequence Enrichment Using Droplet-Based Microfluidics
Jeff Olson
RainDance Technologies, Inc.

Novel Biomarkers for Assessing Epigenetic Instability and Risk of Head and Neck Cancer
Paul M. Lizardi, Ph.D.
Yale University School of Medicine

12:30 p.m. - 1:45 p.m.

Lunch and Posters

1:45 p.m. - 4:00 p.m.

Scientific Session IV: New Molecular Tools
Moderator: J. Randy Knowlton, Ph.D.
National Cancer Institute, NIH

Digital Transcriptome Subtraction To Discover New Human Tumor Viruses
Patrick S. Moore, M.D., M.P.H.
University of Pittsburgh Cancer Center

Going After the "Sweet Spot" in Selecting Aptamers for Glycoproteins
Binghe Wang, Ph.D.
Georgia State University

Real-Time PCR Quantification of Precursor and Mature MicroRNAs as a Means To Study Posttranscriptional Regulation of MicroRNAs
Thomas D. Schmittgen, Ph.D.
Ohio State University

One-Step Synthesis of Biofunctionalized Quantum Dots Using DNA Ligands
Shana Kelley, Ph.D.
University of Toronto

4:00 p.m. - 4:15 p.m.


4:15 p.m. - 5:00 p.m.

Keynote Address: Microchannel Resonators for Single Cell Analysis
Scott Manalis, Ph.D.
Massachusetts Institute of Technology

5:00 p.m. - 7:00 p.m.

Poster Session and Reception

7:00 p.m. - 9:00 p.m.

Special Session: Successful Commercialization of a New Biotechnology
President’s Ballroom, Salons A-C
Moderator: Richard Aragon, Ph.D.
National Cancer Institute, NIH

Biomolecular Analysis Using Liquid Crystals
Nicolas L. Abbott, Ph.D.
University of Wisconsin

Commercializing a Disruptive Technology
Laura M. Heisler, Ph.D.
Wisconsin Alumni Research Foundation

Douglas Crawford, Ph.D.
California Institute for Quantitative Biosciences

Technology Transfer: A Tool to Advance Scientific Research for IMAT Researchers
Kevin Brand, J.D.
National Cancer Institute, NIH

Tuesday, October 28, 2008

Special Joint Session With Clinical Proteomics Technologies for Cancer (CPTC) Annual Meeting

7:30 a.m. - 8:00 a.m.

Breakfast, Registration, and CPTC Poster Setup

8:00 a.m. - 8:10 a.m.

Welcome and Introduction
Henry Rodriguez, Ph.D.
National Cancer Institute, NIH

8:10 a.m. - 8:50 a.m.

Keynote Address: Genomic Variation and Disease
David Altsuler, M.D., Ph.D.
Professor of Genetics and Medicine
Harvard Medical School/Massachusetts General Hospital
Program in Medical and Population Genetics
Broad Institute of MIT and Harvard

8:50 a.m. - 12 noon

Special CPTC-IMAT Joint Session: Fostering Collaborative Efforts
Chris Kinsinger, Ph.D.
National Cancer Institute, NIH

J. Randy Knowlton, Ph.D.
National Cancer Institute, NIH

8:50 a.m. - 9:15 a.m.

CPTC Antibody Characterization Pipeline-Grand Opening
Tara Hiltke, Ph.D.
National Cancer Institute, NIH

9:15 a.m. - 9:40 a.m.

Technology To Optimize SCFVs for Targeting Therapeutics
Mark J. Federspiel, Ph.D.
Mayo Clinic

9:40 a.m. - 10:05 a.m.

Incorporating IMAT-Developed Technology Into Another NCI Program
Paul Tempst, Ph.D.
Memorial Sloan-Kettering Cancer Center

10:05 a.m. - 10:20 a.m.


10:20 a.m. - 10:45 a.m.

An Integrated Programmatic Environment To Support In-Depth Proteomics and Phosphoproteomics Profiling and Studies of Gas Phase Chemistry of Peptides and Phosphopeptides
Katheryn Resing, Ph.D.
University of Colorado at Boulder

10:45 a.m. - 11:10 a.m.

Performance and Optimization of LC-MS/MS Platforms for Proteomic Analyses: An Interlaboratory Study
Daniel C. Liebler, Ph.D.
Vanderbilt University

11:10 a.m. - 11:35 a.m.

Nanoscaled Detection of the Disease Proteome
Nicolas J. Wang, Ph.D.
Lawrence Berkeley National Laboratory

11:35 a.m. - 12 noon

Verification of Candidate Protein Biomarkers: Reproducibility of MRM-Based Assays
Steven Hall, Ph.D.
University of California, San Francisco

12 noon - 1:30 p.m.

Joint Networking and Poster Session (with Lunch)

1:30 p.m.

IMAT Meeting Adjournment

IMAT attendees are welcome to stay and attend the CPTC meeting.

For more information on the CPTC meeting, please go to:

For more information on the CPTC program, please go to: