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5th Principal Investigators Meeting Agenda

5th Principal Investigators Meeting
Innovative Molecular Analysis Technologies Program
June 28 -30, 2004
Catamaran Resort Hotel
San Diego, California

Agenda

MONDAY, JUNE 28, 2004
7:30 a.m. - 8:45 a.m.   Registration and Breakfast
8:45 a.m. - 9:00 a.m   Welcome
Ed Monachino, NCI
9:00 a.m. - 9:30 a.m.  

NCI Technology Initiatives
Greg Downing, D.O., Ph.D., NCI

Session 1—Generating the Knowledge Base for Cancer Research
9:30 a.m. - 10:00 a.m.  

End of Sequence Profiling (ESP): The Structural Analysis of Tumor Genomes
Colin Colins, Ph.D., University of California - San Francisco

10:00 a.m. - 10:30 a.m  

Protein Knockout, A Novel Reverse Genetic Tool for Dissecting the Function of Oncoproteins During Normal Development and in Antagonizing Tumorgenicity
Pengbo Zhou, Ph.D., Weill Medical College of Cornell University

10:30 a.m. - 11:00 a.m.   BREAK
11:00 a.m. - 11:30 a.m.  

Identification of Frequent Chromosomal Aberrations in Hepatocellular Carcinoma from Gene Expression Microarray Data
Kyle Furge, Ph.D., Van Andel Research Institute

11:30 a.m. - 12:00 p.m  

Functional-Based Identification of New Target Genes for Cancer
Brian Davis, Ph.D., Ordway Research Institute

12:00 p.m. - 1:00 p.m.   LUNCH
Managing Intellectual Property in Academia and through Commercial Ventures
1:00 p.m. - 1:30 p.m.  

From Idea to Clinic: Aligning the Stakeholders to Generate Clinical Tests from Research Ideas
Kathy Danenberg, Ph.D, Response Genetics, Inc., and UCLA

1:30 p.m. - 2:00 p.m.  

Institutional Concerns about Technology Transfer and Intellectual Property
Kathy Ku, M.S.C.E., Stanford University

2:00 p.m. - 2:30 p.m.  

NIH-Sponsored Research and Technology Transfer
Karen Maurey, M.S., NCI-TTO

2:30 p.m. - 3:00 p.m.  

Bridging the Funding Gap
Paul Radspinner, M.B.A., Wisconsin Alumni Research Foundation

3:00 p.m. - 3:30 p.m.   BREAK
3:30 p.m. - 4:00 p.m.  

New Concepts on FDA Guidance for Genetic and Genomic Technologies
Elizabeth Mansfield, Ph.D., FDA

4:30 p.m. - 5:00 p.m.  

NCI IP Policy Change
Greg Downing, D.O., Ph.D., NCI

5:00 p.m. - 6:00 p.m   Panel Discussion: Dannenberg, Ku, Maurey, Radspinner, Mansfield, Downing
6:00 p.m. - 9:00 p.m.   Poster Session

TUESDAY, JUNE 29, 2004
7:30 a.m. - 8:30 a.m.   Registration & Breakfast
8:30 a.m. - 9:30 a.m.  

Keynote: Modeling Tumors as Complex Biosystems
Tom Deisboeck, Ph.D., Harvard University

Session 2—Creating Tools for Discovery
9:30 a.m. - 10:00 a.m.  

Development of a Self Assembling Protein Array
Niroshan Ramachandran, Ph.D., Harvard Medical School

10:00 a.m. - 10:30 a.m.  

Optomechanical Chips for Molecular Profiling of Cancer
Arun Majumdar, Ph.D., University of California - Berkeley

10:30 a.m. - 11:00 a.m.   BREAK
11:00 a.m. - 11:30 a.m.  

PAP: A Platform Technology
Steve Sommer, M.D., Ph.D., City of Hope National Medical Center/Beckman Research Institute

11:30 a.m. - 12:00 p.m.  

Rapid and Sensitive Genetic Mutation Detection by Tandem SSCP/Heteroduplex Analysis in a Microchip Electrophoresis System
Annelise Barron, Ph.D., Northwestern University

12:00 p.m. - 1:00 p.m.   LUNCH
Session 3 - Moving New Tools into the Lab & Clinic
1:00 p.m. - 1:30 p.m.  

Recovery of DNA, RNA, and Protein from Archival Formalin-Fixed, Paraffin-Embedded Tissue Sections Based on the Antigen Retrieval Principle
Clive Taylor, M.D., Ph.D., University of Southern California

1:30 p.m. - 2:00 p.m.  

Use of Oligonucleotide-Based Microarray to Interrogate Promoter Hypermethylation
Tim Huang, Ph.D., The Ohio State University Comprehensive Cancer Center

2:00 p.m. - 2:30 p.m.  

Profiling Ras-Activated Signal Transduction Pathways
Nancy Allbritton, M.D., Ph.D., University of California - Irvine

2:30 p.m. - 3:00 p.m.  

Gel Protein Extraction Platform for Ultrasensitive Gel Protein Identification
Cheng Lee, Ph.D., Calibrant Biosystems

3:00 p.m. - 3:30 p.m.   BREAK
3:30 p.m. - 4:00 p.m.  

IMAT RFAs
Greg Downing, D.O., Ph.D., NCI

4:00 p.m. - 4:15 p.m.  

SBIR Update
Jennifer Couch, Ph.D., NCI

4:15 p.m. - 5:00 p.m.  

Beyond IMAT: Other NIH and NCI Funding Opportunities
Jennifer Couch, Ph.D.; NCI, Tracy Lugo, Ph.D., NCI

5:00 p.m. - 9:00 p.m.   Poster Session

WEDNESDAY, JUNE 30, 2004
7:30 a.m. - 8:30 a.m .   Registration & Breakfast
8:30 a.m. - 9:30 a.m.  

Keynote: Challenges and Opportunities in Translational Cancer Research
Cheryl Willman, M.D., University of New Mexico

Session 4 - Human Cancer Care
9:30 a.m. - 10:00 a.m.  

Gene-specific DNA Methylation for Cancer Diagnosis: A Study of 53 Promoters in 10 Breast Cancer Patients
Victor Levenson, M.D., Ph.D. Robert H. Lurie Comprehensive Cancer Center

10:00 a.m. - 10:30 a.m.  

Proteomics of Hepatic Neoplasia in a Synchronous Rat Model Ruth Hogue Angeletti, Ph.D., Albert Einstein College of Medicine

10:30 a.m. - 11:00 a.m.   BREAK
11:00 a.m. - 11:30 a.m.  

Bcr-Abl Kinase Assays for Gleevec Resistance in Chronic Myeloid Leukemia
Steve Kron, M.D., Ph.D., University of Chicago

11:30 a.m. - 12:00 p.m.   Panel Discussion: Speakers from Session 1 and 2
12:00 p.m.   ADJOURN