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4th Principal Investigators Meeting Agenda

4th Principal Investigators Meeting
Innovative Molecular Analysis Technologies Program
June 16-18, 2003
Hilton San Diego Resort
San Diego, California


MONDAY - JUNE 16, 2003
7:30-8:15 a.m.   Registration and Breakfast
8:15 a.m.   Welcome
Ed Monachino, NCI
8:30 a.m.   Keynote 1: Trends and Perspectives in Cancer Research
Gordon Mills, M.D., Ph.D., University of Texas M.D. Anderson Cancer Center
Session 1—Generating the Knowledge Base for Cancer Research
9:30 a.m.   Endothelial Cell Molecular Alterations in Cancer
Daniel Kenan, M.D., Ph.D., Duke University
10:00 a.m.   BREAK
10:30 a.m.   Real-time in vivo Imaging of Gene Expression by SMaRTTM (Spliceosome Mediated RNA Trans-splicing)
Gerard McGarrity, Ph.D., Intronn, Inc.
11:00 a.m.   Use of 2-D Gel/Mass Spectrometry and Oligonucleotide DNA Microarrays to Study Tumor Protein Production in vivo and in vitro
Alvin Beitz, Ph.D., University of Minnesota
11:30 a.m.   Translating a Transcriptome: High-throughput Analysis of mRNA Translation
David Morris, Ph.D., University of Washington
12:00 noon   LUNCH
Session 2—Creating Tools for Discovery
1:00 p.m.   Intelligent Mapping of Gene Expression Profiles
Zuyi Wang, Ph.D., Catholic University of America
1:30 p.m.   Surface Plasmon Enhanced Microscopy; A New Technology with Optical Resolution of 10nm
Dale Larson, M.S., Harvard Medical School
2:00 p.m.   SH2 profiling: classifying tumor cells on the basis of global tyrosine phosphorylation state
Bruce Mayer, Ph.D., University of Connecticut
2:30 p.m.   Nucleic Acid-Based Biosensors as Tools for Cancer Research and Drug Discovery
Martin Stanton, Ph.D., Archemix Corporation
3:00 p.m.   BREAK
NCI Funding Opportunities for IMAT Technology
3:30 p.m.   DCB (basic research tools, mouse models, etc.) Dan Gallahan, Ph.D.
3:50 p.m.   DCP (prevention, early detection, EDRN) Sudhir Srivastava, Ph.D., M.P.H.
4:10 p.m.   DTP (drug discovery/development) Ron Dubois, Ph.D.
4:30 p.m.   CDP (diagnosis, prognosis) Tracy Lugo, Ph.D.
5:00-5:30 p.m.   Review and Transition Process
Dan Gallahan, Ph.D.
5:00-9:00 p.m.   Poster Session and Interface with NCI programs
TUESDAY - JUNE 17, 2003
7:00-8:00 a.m.   Registration
Session 1: IP Tech Transfer
8:00 a.m.   University Technology Transfer; Perspectives, Policies and Practical Advice
Irene Abrams, M.A., Massachusetts Institute of Technology
8:45 a.m.   Commercialization: Entrepreneurs in the New Landscape of Biotech Investment
Allen Baker, C.Phil., Dawnbreaker
Session 2: Moving Technology in a Clinical Direction
9:30 a.m.   The Long and Winding Road: From Research Diagnostics to Clinical Implementation
Steve Piccoli, Ph.D., Fujirebio Diagnostics, Inc.
10:15 a.m.   in vitro Diagnostics—Overview
Maria Chan, Ph.D., CDRH, FDA
11:00 a.m.   Panel Discussion: Speakers from Session 1 and 2
12:00 noon   LUNCH
1:00 p.m.   Keynote 2: How to Move Tech Forward
Dr Steve Lee, Ph.D., Ohio State University
Session 3: Moving New Tools into the Lab & Clinic
1:30 p.m.   Functional Proteomics to Identify Proteins in Cancer Cell Invasion
Dan Jay, Ph.D., Tufts University
2:00 p.m.   Epigenomic Changes During Leukemia Cell Differentiation: Analysis of Histone Acetylation and Cytosine Methylation Using CpG Island Microarrays
Bernard Futscher, Ph.D., Univeristy of Arizona
2:30 p.m.   Rapid Molecular Detection of PML/RAR Using Electrochemical Sensorarray
Vincent Gau, Ph.D., Genefluidics, Inc.
3:00 p.m.   Vertical Coverage Arrays in Analyzing Transcription
John Welsh, Ph.D., Sidney Kimmel Cancer Center
3:30 p.m.   BREAK
4:00 p.m.   Update on the SBIR program
Jennifer Couch, Ph.D.and Anne Heath
5:00-9:00 p.m.   Poster Session
7:30-8:30 a.m.   Breakfast
8:30 a.m.   Keynote 3: Genomic Analyses of Clinical Breast Cancer
Suzanne Fuqua, Ph.D., Baylor College of Medicine
Session 4 —Exploring Human Cancer
9:30 a.m.   Methylated CpG Island Amplification for Methylation Profiling of Cancer
Jean-Pierre Issa, M.D., University of Texas at M.D. Anderson Cancer Center
10:00 a.m.   Vascular Proteomics: Mapping Targets on Endothelia and Caveolae in vivo for Organ- and Tumor-Directed Delivery and Transcytosis
Jan Schnitzer, M.D., Sidney Kimmel Cancer Center
10:30 a.m.   BREAK
11:00 a.m.   Assessment of Plasma DNA levels, Allelic Imbalance and CA-125 as Diagnostic Tests for Cancer
Ie-Ming Shih, M.D., Ph.D., Johns Hopkins University
11:30 a.m.   Gene Expression Profiling of Unknown Primary Cancers
Dr Branimir Sikic, M.D., Stanford University
12:00 noon   Adjourn