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2nd Principal Investigators Meeting Agenda

2nd Principal Investigators Meeting
Innovative Molecular Analysis Technologies Programs
June 27-29, 2001
Washington, DC



6:30 a.m. - 8:30 a.m.


7:30 a.m. - 8:30 a.m.


8:30 a.m. - 8:50 a.m.

Welcoming Remarks
Dr. Carol Dahl, Director, Office of Technology and Industrial Relations (OTIR), NCI

8:50 a.m. - 9:00 a.m.

Session 1: Highlights in DNA Analysis
Session Chair: D r. Graham Brock, University of Glasgow

9:00 a.m. - 9:25 a.m.

Identification of m5CpG Alterations Associated with Breast Carcinomas
Dr. Graham Brock, University of Glasgow

9:25 a.m. - 9:50 a.m.

DNA Damage Quantitation by Single Molecule Laser Sizing
Dr. John Sutherland, Brookhaven National Laboratory

9:50 a.m. - 10:15 a.m.

Detecting Gene Copy Number Fluctuations with Microarrays of Genomic
Dr. Michael Wigler, Cold Spring Harbor Laboratory

10:15 a.m. - 10:40 a.m.


10:40 a.m. - 11:05 a.m.

Four Color Array-bound SNP/Mutation Detection in Cancer
Dr. Paolo Fortina, The Children's Hospital of Philadelphia

11:05 a.m. - 11:30 a.m.

Digital Optical Chemistry; A Novel System for the Rapid Fabrication of Custom Oligonucleotide Arrays
Dr. Harold Garner, University of Texas Southwestern

11:30 a.m. - 12:00 noon

The Early Detection Research Network
Dr. Sudhir Srivastava, Chief, Cancer Biomarkers Research Group, NCI

12:05 p.m. - 1:00 p.m.


1:00 p.m. - 1:10 p.m.

Session 2: Emerging Technologies for RNA Analysis
Session Chair: Dr. Peter Tolias, Center for Applied Genomics, Public Health Research Institute

1:10 p.m. - 1:35 p.m.

Cancer Classification Based on mRNA Isoforms
Dr. Xiang-Dong Fu, University of California at San Diego

1:35 p.m. - 2:00 p.m.

PNA Interference Mapping: A New Technique for RNA Structural Analysis
Dr. William Strauss, Harvard Institute of Human Genomics

2:00 p.m. - 2:25 p.m.

Strategies for Functional Cloning, Sorting and Expression Profiling of Genes That May Be Relevant to Cancer
Dr. Peter Tolias, Center for Applied Genomics, Public Health Research Institute

2:25 p.m. - 2:50 p.m.

Spectral Imaging for Phenotyping Analysis of Cancer Cells
Dr. Heinz-Ulrich Weier, E.O. Lawrence Berkeley National Laboratory

2:50 p.m. - 3:10 p.m.


3:10 p.m. - 3:35 p.m.

Statistical Design and Analysis for Gene Expression Microarrays
Dr. Gary Churchill, The Jackson Laboratory

3:35 p.m. - 4:00 p.m.

Web Presentations:

4:00 p.m. - 5:30 p.m.

NCI Resources
Ms. Susan Waldrop, Director, Office of Scientific Opportunities, NCI

4:00 p.m. - 4:45 p.m.

Tissue Resources
Dr. Roger Aamodt, Chief, Resources Development Branch, NCI

4:45 p.m. - 5:30 p.m.

Technology and Industrial Relations
Dr. Carol Dahl, Director, OTIR, NCI

5:30 p.m. - 10:00 p.m.



6:30 a.m. - 8:00 a.m.


7:00 a.m. - 8:00 a.m.


8:00 a.m. - 8:10 a.m.

Session 3: Advances in Protein Expression Analysis
Session Chair: Dr. John Yates, The Scripps Research Institute

8:10 a.m. - 8:35 a.m.

Protein Detection using Aptamer Beacons
Dr. Martin Stanton, Brandeis University

8:35 a.m. - 9:00 a.m.

Development of Quantum Dot Based Probes for Multiplexed Breast Cancer Analysis
Dr. Marcel Bruchez, Quantum Dot Corporation

9:00 a.m. - 9:25 a.m.

Integrated Isolation & Molecular Analysis of Tumor Cells
Dr. Peter Gascoyne, UT M.D. Anderson Medical Center

9:25 a.m. - 9:50 a.m.

The Single Cell Proteome Project: Cancer Prognosis
Dr. Norman Dovichi, University of Washington

9:50 a.m. - 10:10 a.m.


10:10 a.m. - 10:35 a.m.

Profiling Proteome using Multi-Dimensional Separations for Protein and Peptide Analysis
Dr. John Yates, The Scripps Research Institute

10:35 a.m. - 11:00 a.m.

Reliable Protein Identification from Stained or Unstained 2D Gels using High Throughput MALDI TOF/TOF MS
Dr. Maria Pallavicini, University of California at San Francisco

11:00 a.m. - 12:30 p.m.

Special Session: Phased Innovation Awards: Review and Transitions
Ms. Kay Etzler, NCI Small Business Programs Coordinator, OTIR, NCI
Dr. Dan Gallahan, Chief, Structural Biology and Molecular Applications Branch, NCI
Dr. Sherwood Githens, Scientific Review Administrator, Division of Extramural Activities, NCI

12:30 p.m. - 1:30 p.m.


1:30 p.m. - 1:40 p.m.

Session 4: New Strategies for Protein Structure and Function Analysis
Session Chair: Dr. Brian Chait, Rockefeller University

1:40 p.m. - 2:05 p.m.

Comprehensive Map of Cellular Protein Interactions
Dr. Brian Chait, Rockefeller University

2:05 p.m. - 2:30 p.m.

Novel Proteomics Methodologies for Examining Protein-Protein Interactions in Cancer Biology
Dr. Mark Chance, Albert Einstein College of Medicine

2:30 p.m. - 2:55 p.m.

Integrated Optical/Magnetic Resonance Microscopy for Cellular Research
Dr. Robert Wind, Pacific Northwest National Laboratory

2:55 p.m. - 3:15 p.m.


3:15 p.m. - 3:40 p.m.

Visible Animal Models of Neoplastic Disease
Dr. Christopher Contag, Stanford University

3:40 p.m. - 4:05 p.m.

In vivo Imaging of Matrix Metalloprotease
Dr. Ching Tung, Massachusetts General Hospital

4:05 p.m. - 4:30 p.m.

Androgen Receptor Bio-Chips: Yeast Based Micro-Bioassays for Serum Androgens
Dr. Tanya Kanigan, BioTrove

4:30 p.m. - 6:00 p.m.

Web Presentations:

4:30 p.m. - 5:15 p.m.

Cancer Genomics: Molecular Signatures to Targets
Dr. Bob Strausberg, Director, Cancer Genomics Office, NCI

5:15 p.m. - 10:00 p.m.


FRIDAY, JUNE 29, 2001

7:00 a.m. - 8:00 a.m.


8:00 a.m. - 9:00 a.m.

Plenary Lecture: Technology Transfer: Defining and Capturing Intellectual Property
Dr. Kathleen Sybert, Chief, Technology Transfer Branch, NCI

9:00 a.m. - 9:10 a.m.

Session 5: Molecular Analysis in Cancer Research
Session Chair: Dr. Donna Albertson, University of California at San Francisco

9:10 a.m. - 9:35 p.m.

Genome-Wide Measurement of DNA Copy Number on BAC Microarrays
Dr. Donna Albertson, University of California at San Francisco

9:35 a.m. - 9:50 a.m.

Molecular Analysis of a Large Series of B-Cell non-Hodgkin's Lymphoma
Dr. Wing Chan, University of Nebraska Medical Center

9:50 a.m. - 10:20 a.m.


10:20 a.m. - 10:45 a.m.

Identification of Ovarian Cancer Biomarkers by Protein Chip Array and SELDI/Mass Spectroscopy
Dr. Samuel Mok, Brigham and Women's Hospital

10:45 a.m. - 11:10 a.m.

The National Ovarian Early Detection Program: Combining Science and Technology to Improve Patient Care
Dr. David Fishman, Northwestern University

12:10 p.m.

Closing Remarks
Dr. Carol Dahl, Director, OTIR, NCI