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7th Principal Investigators Meeting Agenda

7th Principal Investigators Meeting
Innovative Molecular Analysis Technologies Program
September 7-8, 2006
Bethesda Marriot Hotel (Pooks Hill)
Bethesda, Maryland



7:30 a.m. - 8:30 a.m.

Registration and Continental Breakfast

7:30 a.m. - 8:30 a.m.

Poster Setup

8:30 a.m. - 8:50 a.m.

Welcoming Remarks
Gregory J. Downing, D.O., Ph.D.
National Cancer Institute

8:50 a.m. - 9:50 a.m.

Keynote Presentation
Systems Approaches to Predictive Marker Development
Joe W. Gray, Ph.D.
Lawrence Berkeley National Laboratory

9:50 a.m. - 10:00 a.m.


10:00 a.m. - 12:20 p.m.

Session 1: Sample Preparation
Moderator: Rebecca L. Huppi, Ph.D.
National Cancer Institute

Determining Agreement in Molecular Data Across Different Methods of Tissue Procurement
Philip S. Bernard, M.D.
Huntsman Cancer Institute

Recovery of Protein From Formalin-Fixed Paraffin- Embedded Tissue
Timothy O'Leary, M.D., Ph.D.
Veterans Health Administration

A Chip-Based RNA Sensor Platform for Detection of Circulating Tumor Cells
Gary A. Clawson, M.D., Ph.D.
Pennsylvania State University

Microfluidic Platform for Live Cell Screening
Philip Lee, Ph.D.
CellASIC Corporation

12:20 p.m. - 1:20 p.m.


1:20 p.m. - 2:05 p.m.

Electronic Submissions and Alternative Funding Opportunities

SF424/Electronic Transition Requirements
Scarlett Gibb
National Institutes of Health

Alternative Funding Opportunities
Jennifer Couch, Ph.D.
National Cancer Institute

2:05 p.m. - 2:15 p.m.


2:15 p.m. - 4:15 p.m.

Session 2: Proteomics
Moderator: Paul Wagner, Ph.D.
National Cancer Institute

Mapping Endothelium and Its Caveolae In Vivo to Improve Antibody Pentetration, Imaging, and Therapy of Solid Tumors
Jan E. Schnitzer, M.D.
Sidney Kimmel Cancer Center

Diverse Novel Approaches for Proteomics of Posttranslational Modifications
Yingming Zhao, Ph.D.
University of Texas Southwestern Medical Center

Selective Profiling of Proteins in Cancer Cells From Fine-Needle Aspirates by MALDI-TOF Mass Spectrometry
Michelle L. Reyzer, Ph.D.
Vanderbilt University

Detection and Identification of Cysteine Sulfenic Acids in Proteins Involved in Signal Transduction Pathways
Leslie B. Poole, Ph.D.
Wake Forest University School of Medicine

Nanoparticles for Efficient Delivery to Solid Tumors
Suzie Pun, Ph.D.
University of Washington

4:15 p.m. - 5:45 p.m.

Poster Session



8:00 a.m. - 9:00 a.m.

Registration and Continental Breakfast

9:00 a.m. - 11:30 a.m.

Session 3: Cellular Imaging
Moderator: Jennifer Couch, Ph.D.
National Cancer Institute

Identifying the Cancer Stem Cell: Lessons Learned From Hematopoiesis and Acute Leukemia
Scott W. Hiebert, Ph.D.
Vanderbilt University

Automated Cell Preparation in Tubes for 3D Microscopy
Mark R. Holl, Ph.D.
University of Washington

Imaging Transcriptional Activation in Gliomas
E. Antonio Chiocca, M.D., Ph.D.
James Cancer Hospital and Solove Research Institute

Sensing and Imaging Activated Fibroblast in Tumor Stroma
Ching Tung, Ph.D.
Massachusetts General Hospital/Harvard Medical School

Age-Dependent Accumulation of Recombinant Cells in the Mouse Pancreas Revealed In Situ by Fluorescence Imaging
Bevin Engleward, Ph.D.
Massachusetts Institute of Technology

11:30 a.m. - 12:30 p.m.


12:30 p.m. - 2:30 p.m.

Session 4: Molecular Biology
Moderator: J. Randy Knowlton, Ph.D.
National Cancer Institute

Development of High-Throughput Methods for the in vitro Selection of RNA Aptamers That Can Distinguish Between Tumor Cell Types
Andrew D. Ellington, Ph.D.
University of Texas at Austin

Facile Characterization of Protein Structure/Function With Enhanced Peptide Amide Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)
Virgil L. Woods, Jr., M.D.
University of California, San Diego

Analysis of Genetic and Epigenetic Alterations in DNA Archives Generated From Tumors of the Head and Neck
Paul M. Lizardi, Ph.D.
Yale University School of Medicine

Prostate Cancer Gene Discovery Using Transposon-Based Somatic Mutagenesis
Lara S. Collier, Ph.D.
University of Minnesota Cancer Center

Solid-Phase Assays of Oncogenic Tyrosine Kinase Activity for Use in Diagnostics and Drug Discovery
Stephen J. Kron, M.D., Ph.D.
University of Chicago

2:30 p.m. - 3:00 p.m.

Closing Remarks

3:00 p.m.

Adjournment and Poster Removal